Preheat your oven to 400°F (200°C).
In a mixing bowl, combine the olive oil, garlic powder, onion powder, paprika, salt, black pepper, and Italian seasoning (if using) to create a marinade.
Pat the chicken breasts dry with paper towels and then add them to the bowl, ensuring they are well-coated with the marinade on all sides.
Place the seasoned chicken breasts in a baking dish and drizzle any remaining marinade over the top.
Bake uncovered in the preheated oven for 25 minutes, or until the chicken is cooked through and has reached an internal temperature of 165°F (75°C). Use a meat thermometer to check the temperature for accuracy.
If desired, cover the chicken with aluminum foil and let it rest for 5 minutes before slicing. This helps retain the juices.
Serve the chicken hot, with fresh lemon wedges for added flavor, if desired.